Nonobese diabetic mice and the genetics of diabetes susceptibility

被引：24
|
作者：
Leiter E.H. [1 ]
机构：
[1] The Jackson Laboratory, Bar Harbor, ME 04609
来源：
Current Diabetes Reports | 2005年 / 5卷 / 2期
基金：
美国国家卫生研究院;
关键词：
Major Histocompatibility Complex; Major Histocompatibility Complex Class; Experimental Allergic Encephalomyelitis; Congenic Strain; Diabetes Susceptibility;
D O I：
10.1007/s11892-005-0042-z
中图分类号：
学科分类号：
摘要：
The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated type I diabetes (TID). Common and rare alleles both within a diabetogenic major histocompatibility complex (MHC) and multiple non-MHC genes combine to impair normal communication between the innate and acquired immune system, leading to loss of immune tolerance. An understanding of how variable collections of genes interact with each other and with environmental cues offers important insights as to the complexities of TID inheritance in humans. Copyright © 2005 by Current Science Inc.
引用
收藏
页码：141 / 148
页数：7
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