This study examined perceptions of differential treatment relating to school disciplinary practices in a racially and ethnically diverse sample (Black, South Asian, Asian, White, and “other” racial/ethnic background) of high school students (N = 1870). Participants completed detailed individual questionnaires assessing general perceptions of school disciplinary practices and various aspects of the school environment. Results indicated that racial/ethnic minority students are much more likely than White students to perceive discrimination with respect to teacher treatment, school suspension, use of police by school authorities, and police treatment at school. Multivariate analyses revealed that such perceptions are particular strong for Black students. In addition, a number of other variables such as gender, socioeconomic status, age of immigration, and views of school climate also predicted students' perceptions of differential treatment toward members of their racial/ethnic group. The implications of these findings are discussed, and suggestions for future research are outlined.