In Vitro and in Vivo Antitrypanosomal Activitiy of Two Microbial Metabolites, KS-505a and Alazopeptin

被引：0
|
作者：
Aki Ishiyama
Kazuhiko Otoguro
Miyuki Namatame
Aki Nishihara
Toshiaki Furusawa
Rokuro Masuma
Kazuro Shiomi
Yoko Takahashi
Michio Ichimura
Haruki Yamada
Satoshi Ōmura
机构：
[1] Research Center for Tropical Diseases,
[2] Center for Basic Research,undefined
[3] Kitasato University,undefined
[4] Kitasato Institute for Life Sciences and Graduate School of Infectious Control Sciences,undefined
[5] Kitasato University,undefined
[6] BioFrontier Laboratories,undefined
[7] Kyowa Hakko Kogyo Co.,undefined
[8] Ltd.,undefined
来源：
The Journal of Antibiotics | 2008年 / 61卷
关键词：
screening; antitrypanosomal antibiotics; HAT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Our on-going screening program to discover new antitrypanosomal antibiotics has been evaluating compounds isolated from soil microorganisms as well as investigating the antibiotic libraries of the Kitasato Institute for Life Sciences and BioFrontier Laboratories of Kyowa Hakko Kogyo Co., Ltd. We have now discovered two compounds, KS-505a and alazopeptin, which exhibit moderate antitrypanosomal characteristics. We report here the in vitro and in vivo antitrypanosomal activities and cytotoxicities of KS-505a and alazopeptin, compared with some commonly-used antitrypanosomal drugs. This is the first report of in vitro and in vivo antitrypanosomal activities of either KS-505a or alazopeptin.
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页码：627 / 632
页数：5
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