Disseminated Invasive Aspergillosis with Cerebral Involvement Successfully Treated with Caspofungin and Voriconazole

被引：0
|
作者：
C. Gubler
S. M. Wildi
A. Imhof
M. Schneemann
B. Müllhaupt
机构：
[1] University Hospital of Zurich,Dept. of Gastroenterology and Hepatology
[2] University Hospital of Zurich,Dept. of Medicine
[3] Spital Uster,Clinic of Internal Medicine
来源：
Infection | 2007年 / 35卷
关键词：
Voriconazole; Aspergillosis; Invasive Aspergillosis; Caspofungin; Liposomal Amphotericin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We describe a case of cerebral aspergillosis which was successfully treated with a combination of caspofungin and voriconazole. The patient remains in remission 18 months after stopping antifungal treatment. We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. Since historical data showed a fatal outcome in most cases, amphotericin B does not cross the blood brain barrier while voriconazole does, we chose a combination of voriconazole plus caspofungin as primary therapy.
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页码：364 / 366
页数：2
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