A new role for statins in sepsis

被引：0
|
作者：
Jean-Sebastien Rachoin
Elizabeth Cerceo
R Phillip Dellinger
机构：
[1] Cooper University Hospital,Department of Medicine, Cooper Medical School of Rowan University
来源：
Critical Care | / 17卷
关键词：
Simvastatin; Atorvastatin; Severe Sepsis; Pravastatin; Systemic Inflammatory Response Syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several studies have shown promising results regarding the use of statins as an adjunctive treatment for sepsis. Most of those studies were retrospective or observational in nature. The ASEPSIS trial has reported that the administration of atorvastatin reduced clinical progression of sepsis but did not improve mortality. These findings are promising and further multicenter trials are needed to confirm these outcomes and to establish whether this class of medications will offer utility in this regard.
引用
收藏
相关论文
共 50 条
  • [1] A new role for statins in sepsis
    Rachoin, Jean-Sebastien
    Cerceo, Elizabeth
    Dellinger, R. Phillip
    CRITICAL CARE, 2013, 17 (01)
  • [2] The Role of Statins in Sepsis
    Goncuoglu, Cansu
    Cetinadam, Hafsa Nur
    Demirkan, Kutay
    Unal, Serhat
    FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, 2021, 26 (03): : 369 - 377
  • [3] Statins role in the prevention and treatment of sepsis
    Dobesh, Paul P.
    Olsen, Keith M.
    PHARMACOLOGICAL RESEARCH, 2014, 88 : 31 - 40
  • [4] Understanding the potential role of statins in pneumonia and sepsis
    Yende, Sachin
    Milbrandt, Eric B.
    Kellum, John A.
    Kong, Lan
    Delude, Russell L.
    Weissfeld, Lisa A.
    Angus, Derek C.
    CRITICAL CARE MEDICINE, 2011, 39 (08) : 1871 - 1878
  • [5] Do statins have a role in preventing or treating sepsis?
    Victor Novack
    Marius Terblanche
    Yaniv Almog
    Critical Care, 10
  • [6] Do statins have a role in preventing or treating sepsis?
    Novack, Victor
    Terblanche, Marius
    Almog, Yaniv
    CRITICAL CARE, 2006, 10 (01):
  • [7] Statins and sepsis
    Gao, F.
    Linhartova, L.
    Johnston, A. Mcd.
    Thickett, D. R.
    BRITISH JOURNAL OF ANAESTHESIA, 2008, 100 (03) : 288 - 298
  • [8] Statins and sepsis
    Pechlaner, Christoph
    Wiedermann, Christian
    LANCET, 2006, 367 (9523): : 1651 - 1651
  • [9] Statins in sepsis
    Carrillo-Esper, Raul
    CIRUGIA Y CIRUJANOS, 2008, 76 (02): : 99 - 100
  • [10] Statins and sepsis
    Kruger, P. S.
    BRITISH JOURNAL OF ANAESTHESIA, 2008, 100 (06) : 862 - 862
12345