Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

被引：0
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作者：
Xin Li
Cai-Feng Bi
Yu-Hua Fan
Xia Zhang
Xiao-Dan Wei
Xiang-Min Meng
机构：
[1] Ocean University of China,Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering
来源：
Transition Metal Chemistry | 2014年 / 39卷
关键词：
Schiff base; Copper(II) complex; DNA; Intercalative binding; Cleavage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A ternary coordination complex 2Cu(C14H8NO3Cl)(C12H8N2)·3CH3OH of a Schiff base (C14H8NO3Cl: 4-chloroanthranilic acid–salicylaldehyde) was synthesized from 4-chloroanthranilic acid, salicylaldehyde, copper acetate and 1,10-phenanthroline and characterized by physicochemical and spectroscopic methods. X-ray crystallography shows that the copper atom is five coordinated by the imine nitrogen, two nitrogen atoms from 1,10-phenanthroline, the hydroxyl oxygen and the carboxylate oxygen atom. The interaction of the complex with calf-thymus DNA was investigated by UV absorption spectroscopy, fluorescence emission spectroscopy and viscosity. In addition, the cleavage reaction with pBR322 supercoiled plasmid DNA was investigated. The complex binds to DNA and also exhibits significant DNA cleavage activity.
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页码：577 / 584
页数：7
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