Water soluble sulconazole-β-cyclodextrin complex: physico-chemical characterization and preliminary pharmacological studies

被引：0
|
作者：
Liviu Miron
Mihai Mares
Valentin Nastasa
Mariana Spulber
Adrian Fifere
Mariana Pinteala
Valeria Harabagiu
Bogdan C. Simionescu
机构：
[1] Institute of Macromolecular Chemistry Petru Poni,Department of Parasitology
[2] University of Agricultural Sciences and Veterinary Medicine Ion Ionescu de la Brad, Department of Mycology
[3] University of Agricultural Sciences and Veterinary Medicine,Mycotoxicology
[4] University of Agricultural Sciences and Veterinary Medicine,Department of Pharmacology
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2009年 / 63卷
关键词：
Sulconazole nitrate; Cyclodextrin; Antifungal activity; Acute toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sulconazole-β-cyclodextrin water soluble inclusion complex was prepared by freeze drying method in distilled water. The formation of inclusion complex between β-cyclodextrin and sulconazole has been studied in a previous work. Preliminary pharmacological studies concerning the antifungal activity showed that the minimal inhibitory concentrations for 90% of the tested strains decreased. Also, the acute toxicity of the sulconazole-β-cyclodextrin complex is smaller comparing with the pure drug, analyzed alone. These results recommend the described conjugates as future promising therapeutic agents.
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页码：159 / 162
页数：3
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