Survival and Migration of Rat Olfactory Ensheathing Cells after Transplantation into Posttraumatic Cysts in the Spinal Cord

被引：0
|
作者：
A. D. Voronova
M. P. Valikhov
O. V. Stepanova
P. A. Mel’nikov
A. V. Chadin
K. N. Sidoruk
A. S. Semkina
M. A. Abakumov
I. V. Reshetov
V. P. Chekhonin
机构：
[1] Ministry of Health of the Russian Federation,Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology
[2] N. I. Pirogov National Research Medical University,Department of Medical Nanobiotechnologies, Medical and Biological Faculty
[3] University Clinical Hospital No. 1,Department of Neurohumoral and Immunological Studies, National Medical Research Center of Cardiology
[4] I. M. Sechenov First Moscow State Medical University,undefined
[5] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
关键词：
olfactory ensheathing cells; olfactory mucosa; cell survival; cell therapy; posttraumatic spinal cord cysts;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied survival of rat ensheathing cells after transplantation into experimental posttraumatic cysts. These cells were prepared according to our original protocol, labeled with intravital membrane dye PKH26, and transplanted into posttraumatic cysts of the spinal cord. The presence of cysts was verified by magnetic resonance imaging. Olfactory ensheathing cells were detected in the spinal cord by the immunofluorescence method. It was shown that rat olfactory ensheathing cells survived in the spinal cord over 4 weeks and their migration was observed. High survival rate and the possibility of obtaining olfactory ensheathing cells from the olfactory mucosa of patients for creation of an autologous preparation allow considering them as very promising material for the treatment of patients with posttraumatic cysts of the spinal cord.
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页码：118 / 123
页数：5
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