Effect of the a7nAChR agonist GTS-21 on inflammation during human endotoxemia

被引:0
|
作者
J Pompe
M Kox
C Hoedemaekers
P Pickkers
A Van Vugt
J Van der Hoeven
机构
[1] Radboud University Nijmegen Medical Centre,
来源
Critical Care | / 13卷 / Suppl 1期
关键词
Vagus Nerve; Vagus Nerve Stimulation; Healthy Human Volunteer; Experimental Arthritis; Experimental Endotoxemia;
D O I
10.1186/cc7523
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [1] The selective α7nAChR agonist GTS-21 attenuates ventilator-induced inflammation and lung injury
    Kox, Matthijs
    Peters, Esther
    Vaneker, Michiel
    Scheffer, Gert-Jan
    van der Hoeven, Johannes
    Pickkers, Peter
    [J]. INFLAMMATION RESEARCH, 2010, 59 : S31 - S32
  • [2] THE SELECTIVE α7NACHR AGONIST GTS-21 ATTENUATES VENTILATOR-INDUCED INFLAMMATION AND LUNG INJURY
    Kox, M.
    Pompe, J. C.
    Vaneker, M.
    Heunks, L. M.
    van der Hoeven, J. G.
    Hoedemaekers, C. W.
    Pickkers, P.
    [J]. INTENSIVE CARE MEDICINE, 2009, 35 : 214 - 214
  • [3] α7-nAchR agonist GTS-21 reduces radiation-induced lung injury
    Mei, Zijie
    Tian, Xiaoli
    Chen, Jing
    Wang, Yacheng
    Yao, Ye
    Li, Xin
    Yang, Chunxu
    Zhang, Shimin
    Xie, Conghua
    [J]. ONCOLOGY REPORTS, 2018, 40 (04) : 2287 - 2297
  • [4] GTS-21 reduces microvascular permeability during experimental endotoxemia
    Schmidt, Karsten
    Bhakdisongkhram, Sukanya
    Uhle, Florian
    Philipsenburg, Christoph
    Zivkovic, Aleksandar R.
    Brenner, Thorsten
    Motsch, Johann
    Weigand, Markus A.
    Hofer, Stefan
    [J]. MICROVASCULAR RESEARCH, 2018, 115 : 75 - 82
  • [5] GTS-21, an A7-NACHR agonist, down-regulates TNF-a and protects in shock.
    Al-Abed, Y
    Wang, H
    Amella, CAA
    Tonovic, M
    Ochani, M
    Tracey, K
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 227 : U59 - U59
  • [6] GTS-21 Promotes α7 nAChR to Alleviate Intestinal Ischemia-Reperfusion-Induced Apoptosis and Inflammation of Enterocytes
    Wang, Haisong
    Cai, Dongmiao
    Chen, Zhenyi
    Wang, Yanlin
    [J]. MEDICAL SCIENCE MONITOR, 2020, 26
  • [7] Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory
    Yang, X.
    Zhao, C.
    Chen, X.
    Jiang, L.
    Su, Xiao
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2017, 110 (07) : 437 - 445
  • [8] Alpha7 Nicotinic Acetylcholine Receptor (α7nAChR) Agonist GTS-21 Regulates Glycemic Control and Gut Hormones
    Pruekprasert, Napat
    Meng, Qinghe
    Liu, Chunli
    Xie, Han
    Cooney, Robert N.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2019, 229 (04) : S16 - S17
  • [9] Selective α7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Pavlov, Valentin A.
    Ochani, Mahendar
    Yang, Li-Hong
    Gallowitsch-Puerta, Margot
    Ochani, Kanta
    Lin, Xinchun
    Levi, Jelena
    Parrish, William R.
    Rosas-Ballina, Mauricio
    Czura, Christopher J.
    LaRosa, Gregory J.
    Miller, Edmund J.
    Tracey, Kevin J.
    Al-Abed, Yousef
    [J]. CRITICAL CARE MEDICINE, 2007, 35 (04) : 1139 - 1144
  • [10] Neuroprotective effects of nicotine and GTS-21 via α7 nAChR in rat hippocampal slice cultures
    Takahashi, Sayaka
    Tanaka, Sachiko
    Itoh, Yoshitsugu
    Numazawa, Satoshi
    Yoshida, Takemi
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010, 112 : 136P - 136P