The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

被引：0

作者：

Minghui Wang

Noam D. Beckmann

Panos Roussos

Erming Wang

Xianxiao Zhou

Qian Wang

Chen Ming

Ryan Neff

Weiping Ma

John F. Fullard

Mads E. Hauberg

Jaroslav Bendl

Mette A. Peters

Ben Logsdon

Pei Wang

Milind Mahajan

Lara M. Mangravite

Eric B. Dammer

Duc M. Duong

James J. Lah

Nicholas T. Seyfried

Allan I. Levey

Joseph D. Buxbaum

Michelle Ehrlich

Sam Gandy

Pavel Katsel

Vahram Haroutunian

Eric Schadt

Bin Zhang

机构：

[1] Icahn School of Medicine at Mount Sinai,Department of Genetics and Genomic Sciences

[2] One Gustave L. Levy Place,Department of Psychiatry

[3] Icahn Institute of Genomics and Multiscale Biology,Department of Biomedicine

[4] Icahn School of Medicine at Mount Sinai,Department of Biochemistry

[5] One Gustave L. Levy Place,Department of Neurology

[6] Icahn School of Medicine at Mount Sinai,Department of Neurology

[7] One Gustave L. Levy Place,Department of Pediatrics

[8] Friedman Brain Institute,Fishberg Department of Neuroscience

[9] Icahn School of Medicine at Mount Sinai,undefined

[10] One Gustave L. Levy Place,undefined

[11] Psychiatry,undefined

[12] JJ Peters VA Medical Center,undefined

[13] 130 West Kingsbridge Road,undefined

[14] iPSYCH,undefined

[15] The Lundbeck Foundation Initiative for Integrative Psychiatric Research,undefined

[16] Aarhus University,undefined

[17] Centre for Integrative Sequencing (iSEQ),undefined

[18] Aarhus University,undefined

[19] Sage Bionetworks,undefined

[20] Emory University School of Medicine,undefined

[21] Integrated Proteomics Core Facility,undefined

[22] Emory University School of Medicine,undefined

[23] Emory University School of Medicine,undefined

[24] Center for Neurodegenerative Disease,undefined

[25] Emory University School of Medicine,undefined

[26] Seaver Autism Center for Research and Treatment,undefined

[27] Icahn School of Medicine at Mount Sinai,undefined

[28] One Gustave L. Levy Place,undefined

[29] Icahn School of Medicine at Mount Sinai,undefined

[30] One Gustave L Levy Place,undefined

[31] Icahn School of Medicine at Mount Sinai,undefined

[32] One Gustave L Levy Place,undefined

[33] The Alzheimer’s Disease Research Center,undefined

[34] Icahn School of Medicine at Mount Sinai,undefined

[35] One Gustave L Levy Place,undefined

[36] Icahn School of Medicine at Mount Sinai,undefined

[37] One Gustave L. Levy Place,undefined

来源：

Scientific Data | / 5卷

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摘要：

Alzheimer’s disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and can neither provide clinically meaningful prediction of development of AD nor offer actionable mechanisms. This cohort study generated large-scale matched multi-Omics data in AD and control brains for exploring novel molecular underpinnings of AD. Specifically, we generated whole genome sequencing, whole exome sequencing, transcriptome sequencing and proteome profiling data from multiple regions of 364 postmortem control, mild cognitive impaired (MCI) and AD brains with rich clinical and pathophysiological data. All the data went through rigorous quality control. Both the raw and processed data are publicly available through the Synapse software platform.

引用

共 50 条

[1] The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
Wang, Minghui
Beckmann, Noam D.
Roussos, Panos
Wang, Erming
Zhou, Xianxiao
Wang, Qian
Ming, Chen
Neff, Ryan
Ma, Weiping
Fullard, John F.
Hauberg, Mads E.
Bendl, Jaroslav
Peters, Mette A.
Logsdon, Ben
Wang, Pei
Mahajan, Milind
Mangravite, Lara M.
Dammer, Eric B.
Duong, Duc M.
Lah, James J.
Seyfried, Nicholas T.
Levey, Allan I.
Buxbaum, Joseph D.
Ehrlich, Michelle
Gandy, Sam
Katsel, Pavel
Haroutunian, Vahram
Schadt, Eric
Zhang, Bin
[J]. SCIENTIFIC DATA, 2018, 5
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