Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

被引：0
|
作者：
Alex K. Shalek
Rahul Satija
Xian Adiconis
Rona S. Gertner
Jellert T. Gaublomme
Raktima Raychowdhury
Schraga Schwartz
Nir Yosef
Christine Malboeuf
Diana Lu
John J. Trombetta
Dave Gennert
Andreas Gnirke
Alon Goren
Nir Hacohen
Joshua Z. Levin
Hongkun Park
Aviv Regev
机构：
[1] Harvard University,Department of Chemistry and Chemical Biology and Department of Physics
[2] 12 Oxford Street,Department of Pathology & Center for Systems Biology and Center for Cancer Research
[3] Cambridge,Center for Immunology and Inflammatory Diseases & Department of Medicine
[4] Massachusetts 02138,Department of Biology
[5] USA,undefined
[6] Broad Institute of MIT and Harvard,undefined
[7] 7 Cambridge Center,undefined
[8] Massachusetts General Hospital,undefined
[9] Massachusetts General Hospital,undefined
[10] Howard Hughes Medical Institute,undefined
[11] Massachusetts Institute of Technology,undefined
来源：
Nature | 2013年 / 498卷
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摘要：
Single-cell RNA sequencing is used to investigate the transcriptional response of 18 mouse bone-marrow-derived dendritic cells after lipopolysaccharide stimulation; many highly expressed genes, such as key immune genes and cytokines, show bimodal variation in both transcript abundance and splicing patterns. This variation reflects differences in both cell state and usage of an interferon-driven pathway involving Stat2 and Irf7.
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页码：236 / 240
页数：4
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