Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study

被引:0
|
作者
Chen Cui
Shuli Wang
Minjie Lu
Xuejing Duan
Hongyue Wang
Liujun Jia
Yue Tang
Arlene Sirajuddin
Sanjay K. Prasad
Peter Kellman
Andrew E. Arai
Shihua Zhao
机构
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Magnetic Resonance Imaging, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases
[2] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Pathology, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases
[3] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Animal Experimental Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases
[4] National Institutes of Health (NIH),National Heart, Lung and Blood Institute (NHLBI)
[5] Royal Brompton & Harefield NHS Foundation Trust,NIHR Cardiovascular Biomedical Research Unit
[6] US Department of Health and Human Services,Cardiovascular and Pulmonary Branch, National Heart, Lung and Blood Institute, National Institutes of Health
来源
Scientific Reports | / 8卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images. Histological validation was performed using triphenyl tetrazolium chloride (TTC) staining in the corresponding ex-vivo slices. The infarct size and transmural extent of myocardial infarction assessed by T1 mapping correlated well with that assessed by LGE and TTC images. Using TTC staining as the reference, T1 mapping demonstrated underestimation of infarct size and transmural extent of infarction. Additionally, there was a slight but not significant difference found in the diagnostic performance between the native T1 maps and LGE images for the location of MI. Our study shows that native T1 mapping is feasible alternative method to the LGE technique for the assessment of the size, transmural extent, and location of MI in patients who cannot receive gadolinium contrast.
引用
收藏
相关论文
共 50 条
  • [1] Detection of Recent Myocardial Infarction Using Native T1 Mapping in a Swine Model: A Validation Study
    Cui, Chen
    Wang, Shuli
    Lu, Minjie
    Duan, Xuejing
    Wang, Hongyue
    Jia, Liujun
    Tang, Yue
    Sirajuddin, Arlene
    Prasad, Sanjay K.
    Kellman, Peter
    Arai, Andrew E.
    Zhao, Shihua
    SCIENTIFIC REPORTS, 2018, 8
  • [2] Detection of Myocardial Ischemia Using Cardiovascular MRI Stress T1 Mapping: A Miniature-Swine Validation Study
    Zhuang, Baiyan
    Cui, Chen
    He, Jian
    Xu, Jing
    Yin, Gang
    Duan, Xuejing
    Yue, Guangxin
    Wang, Hongyue
    Wang, Xin
    Sirajuddin, Arlene
    Zhao, Shihua
    Lu, Minjie
    RADIOLOGY-CARDIOTHORACIC IMAGING, 2023, 5 (03):
  • [3] Can Chronic Myocardial Infarction Be Detected by Native T1 Mapping?
    Kellman, Peter
    JACC-CARDIOVASCULAR IMAGING, 2022, 15 (12) : 2080 - 2081
  • [4] Native T1 Mapping for Myocardial Infarction Time to Throw Out the Gadolinium?
    Nezafat, Reza
    JACC-CARDIOVASCULAR IMAGING, 2015, 8 (09) : 1031 - 1033
  • [5] Native T1 mapping for characterization of acute and chronic myocardial infarction in swine: Comparison with contrast-enhanced MRI
    Liu, Xi
    Hou, Jiang-long
    Yang, Zhi-gang
    Xia, Chun-chao
    Xie, Lin-jun
    Ye, Peng-fei
    Peng, Wan-lin
    Li, Lei
    Yang, Meng-xi
    Guo, Ying-kun
    JOURNAL OF MAGNETIC RESONANCE IMAGING, 2018, 47 (05) : 1406 - +
  • [6] Native T1 Mapping Adding a New Dimension to the Characterization of Acute Myocardial Infarction
    Garg, Pankaj
    Plein, Sven
    CIRCULATION-CARDIOVASCULAR IMAGING, 2017, 10 (08)
  • [7] Enabling Reliable Visual Detection of Chronic Myocardial Infarction with Native T1 Cardiac MRI Using Data-Driven Native Contrast Mapping
    Youssef, Khalid
    Zhang, Xinheng
    Yoosefian, Ghazal
    Chen, Yinyin
    Chan, Shing Fai
    Yang, Hsin-Jung
    Vora, Keyur
    Howarth, Andrew
    Kumar, Andreas
    Sharif, Behzad
    Dharmakumar, Rohan
    RADIOLOGY-CARDIOTHORACIC IMAGING, 2024, 6 (04):
  • [8] Native Myocardial T1 Mapping, Are We There Yet?
    Hamdy, Ahmed
    Kitagawa, Kakuya
    Ishida, Masaki
    Sakuma, Hajime
    INTERNATIONAL HEART JOURNAL, 2016, 57 (04) : 400 - 407
  • [9] T1 mapping in patients with acute myocardial infarction
    Messroghli, DR
    Niendorf, T
    Schulz-Menger, J
    Dietz, R
    Friedrich, MG
    JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2003, 5 (02) : 353 - 359
  • [10] Histological Validation of Cardiovascular Magnetic Resonance T1 Mapping for Assessing the Evolution of Myocardial Injury in Myocardial Infarction: An Experimental Study
    Zhang, Lu
    Yang, Zhi-gang
    Xu, Huayan
    Yang, Meng-xi
    Xu, Rong
    Chen, Lin
    Sun, Ran
    Miao, Tianyu
    Zhao, Jichun
    Zhou, Xiaoyue
    Fu, Chuan
    Guo, Yingkun
    KOREAN JOURNAL OF RADIOLOGY, 2020, 21 (12) : 1294 - 1304