Optimization of Tumor Radiotherapy Part VI: Modification of Tumor Glucose Metabolism for Increasing the Bioavailability of 2-Deoxy-D-Glucose (2-DG) in a Mutine Tumor ModelPart VI: Modification of Tumor Glucose Metabolism for Increasing the Bioavailability of 2-Deoxy-D-Glucose (2-DG) in a Mutine Tumor Model

Differential radiomodification induced by 2-deoxy-D-glucose (2-DG) is proving to be a feasible modality for optimizing tumor radiotherapy. Our earlier work on Ehrlich ascites tumor cells has shown that pretreatment with hematoporphyrin derivatives increases the uptake and phosphorylation of 2-DG. Moreover, the alteration induced in bioenergetic profile was more drastic and less reversible. The promising combination of hematoporphyrin derivatives and 2-DG has been further evaluated in the Ehrlich ascites tumor bearing mice for determining the effects on radiotherapeutic response.