Open questions on the biological roles of first-row transition metals

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Debbie C. Crans
Kateryna Kostenkova
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[1] 1301 Center Ave.,Department of Chemistry
[2] Colorado State University,Cell and Molecular Biology Program
[3] 1301 Center Ave.,undefined
[4] Colorado State University,undefined
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First-row transition metals play several roles in biological processes and in medicine, but can be toxic in high concentrations. Here the authors comment on the sensitive biochemistry and speciation chemistry of the first-row transition metals, and outline some of the remaining questions that have yet to be answered.
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