Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat

被引：0
|
作者：
E. S. Trofimova
M. V. Zykova
M. G. Danilets
A. A. Ligacheva
E. Yu. Sherstoboev
A. V. Tsupko
D. A. Mikhalyov
M. V. Belousov
机构：
[1] E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine,
[2] Tomsk National Research Medical Center,undefined
[3] Russian Academy of Sciences,undefined
[4] Siberian State Medical University,undefined
[5] Ministry of Health of the Russian Federation,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2021年 / 170卷
关键词：
humic acids; cytokines; humoral immune response; peritoneal macrophages; mononuclear cells;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNFα, IL-1β, and IFNγ by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
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页码：461 / 465
页数：4
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