EZH2-mediated epigenetic repression of DNA repair in promoting breast tumor initiating cells

被引：0
|
作者：
Olafur Andri Stefansson
Manel Esteller
机构：
[1] Bellvitge Biomedical Research Institute,Cancer Epigenetics and Biology Program (PEBC)
[2] 08908 L'Hospitalet,undefined
[3] Institucio Catalana de Recerca i Estudis Avançats,undefined
来源：
Breast Cancer Research | / 13卷
关键词：
Sorafenib; Cancer Stem Cell; Genomic Instability; RAD51 Gene; Epigenetic Inactivation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Members of the Polycomb-group (PcG) family of proteins, including EZH2 (enhancer of zeste homolog 2), are involved in establishing epigenetic silencing of developmental genes in adult and embryonic stem cells, and their deregulation has been implicated in cancer. In a recent report, EZH2-mediated epigenetic repression of DNA damage repair in breast tumor initiating cells (BTICs) was identified as a mechanism that could promote expansion of BTICs, and may contribute to cancer progression.
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