Synthesis of 2-Aryl-4-(R-sulfanylmethyl)-3-methyl-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones

被引：0
|
作者：
V. S. Matiichuk
M. A. Potopnyk
N. D. Obushak
机构：
[1] Ivan Franko Lviv National University,
[2] ul.,undefined
来源：
Russian Journal of Organic Chemistry | 2010年 / 46卷
关键词：
Oxoethyl; Bromoacetyl; Pyridazine Ring; Heterocyclic Thiones; Sulfanylmethyl;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Bromination of ethyl 1-aryl-4-acetyl-5-methyl-1H-pyrazole-3-carboxylates gave ethyl 1-aryl-4-(bromoacetyl)-5-methyl-1H-pyrazol-3-carboxylates which were used to alkylate benzenethiol and heterocyclic thiones at the sulfur atom. Reactions of the resulting S-alkylation products with hydrazine or methylhydrazine involved closure of pyridazine ring to afford 2-aryl-3-methyl-4-[phenyl(or hetaryl)sulfanylmethyl]-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-7-ones.
引用
收藏
页码：1550 / 1557
页数：7
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