Targeting BRCA-mutated tumors in mitosis

被引：0
|
作者：
Demis Menolfi
Shan Zha
机构：
[1] Columbia University,Institute for Cancer Genetics, Vagelos College of Physicians and Surgeons
[2] Columbia University,Division of Pediatric Oncology, Hematology and Stem Cell Transplantation, Department of Pediatrics, Vagelos College of Physicians and Surgeons
来源：
Nature Cancer | 2021年 / 2卷
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摘要：
A genome-wide CRISPR screen finds CIP2A as a new synthetic lethal target for BRCA1- and BRCA2-deficient cells. Unlike PARP inhibition that increases replication-induced DNA double-strand breaks and radial chromosomes, depleting CIP2A or disrupting its interaction with TOPBP1 increases micronuclei and chromosomal missegregation, revealing a mitotic target for BRCA-mutated tumors.
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页码：1296 / 1297
页数：1
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