Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated α-hydroxycarboxylate ligands

被引：0
|
作者：
Rodrigo da Silva Maffei
Jenicer K. U. Yokoyama-Yasunaka
Danilo Ciccone Miguel
Silvia Reni Bortolin Uliana
Breno Pannia Espósito
机构：
[1] Universidade de São Paulo,Instituto de Química
[2] Universidade de São Paulo,Instituto de Ciências Biomédicas
来源：
BioMetals | 2009年 / 22卷
关键词：
Leishmaniasis; Neglected disease; Copper; Fluorine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL2 (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic medium, purified by crystallization and characterized by elemental analysis and electronic and infrared spectroscopies. In vitro experiments with Leishmania amazonensis promastigotes showed that the trifluorolactate derivative more active than its non-fluorinated counterpart. Our results indicate that fluorinated chelators may be interesting to increase metal toxicity and/or open new paths for metallodrug chemotherapy against leishmaniasis.
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页码：1095 / 1101
页数：6
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