Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCα-ERK pathway

被引：0
|
作者：
Moon Ho Park
Dae Hie Lee
机构：
[1] Korea University College of Medicine,Department of Neurology
[2] Seoul 136-705,undefined
[3] Korea.,undefined
来源：
Experimental & Molecular Medicine | 2008年 / 40卷
关键词：
calcium; cell survival; endothelins; mitogen-activated protein kinase 1; neurons; protein kinase C;
D O I：
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学科分类号：
摘要：
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and ET-3) were added to HN33 (mouse hippocampal neuron × neuroblastoma) cells. Among the three types of ET, only ET-1 increased the intracellular calcium levels in a PLC dependent manner with the induction of ERK 1/2 activation. As the result of ET-1 exposure, the survival rate of HN33 cells and the PKCα translocation into the plasma membrane were increased. We suggest that ET-1 participated in the neuroprotective effect involving the calcium-PKCα-ERK1/2 pathway.
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页码：92 / 97
页数：5
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