Epigenetic reprogramming in the mammalian embryo: struggle of the clones

被引：30
|
作者：
Mellissa RW Mann
Marisa S Bartolomei
机构：
[1] University of Pennsylvania School of Medicine,Howard Hughes Medical Institute and Department of Cell and Developmental Biology
来源：
Genome Biology | / 3卷 / 2期
关键词：
Inner Cell Mass; Bovine Embryo; Global Methylation; Preimplantation Development; Paternal Genome;
D O I：
10.1186/gb-2002-3-2-reviews1003
中图分类号：
学科分类号：
摘要：
During preimplantation development in mammals, distinct epigenetic marks on oocyte and sperm DNA are remodeled to an embryonic pattern. A recent study examining global methylation of repetitive elements in various mammals showed that the reprogramming that occurs during normal preimplantation development is aberrant in cloned embryos.
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