Hypoxia and the extracellular matrix: drivers of tumour metastasis

被引：0
|
作者：
Daniele M. Gilkes
Gregg L. Semenza
Denis Wirtz
机构：
[1] Vascular Program,Departments of Pediatrics
[2] Institute for Cell Engineering,Department of Chemical and Biomolecular Engineering
[3] and McKusick-Nathans Institute of Genetic Medicine,Departments of Oncology and Pathology and Sidney Kimmel Comprehensive Cancer Center
[4] Johns Hopkins University School of Medicine,undefined
[5] Johns Hopkins Physical Sciences-Oncology Center,undefined
[6] The Johns Hopkins University,undefined
[7] Oncology,undefined
[8] Medicine,undefined
[9] Radiation Oncology and Biological Chemistry,undefined
[10] Johns Hopkins University School of Medicine,undefined
[11] Johns Hopkins Physical Sciences-Oncology Center,undefined
[12] The Johns Hopkins University,undefined
[13] The Johns Hopkins University,undefined
[14] Johns Hopkins University School of Medicine,undefined
来源：
Nature Reviews Cancer | 2014年 / 14卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Emerging data indicate that hypoxia and the extracellular matrix (ECM) together might have a crucial role in metastasis. In this Opinion article the authors suggest a model in which multiple microenvironmental signals might converge to synergistically influence metastatic outcome.
引用
收藏
页码：430 / 439
页数：9
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