FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

被引：0
|
作者：
Wanzhong He
Mark S. Ladinsky
Kathryn E. Huey-Tubman
Grant J. Jensen
J. Richard McIntosh
Pamela J. Björkman
机构：
[1] Division of Biology 114-96 and,Department of Biological Sciences
[2] ,Department of Molecular
[3] Howard Hughes Medical Institute,undefined
[4] California Institute of Technology,undefined
[5] 1200 East California Boulevard,undefined
[6] Pasadena,undefined
[7] California 91125,undefined
[8] USA ,undefined
[9] National University of Singapore,undefined
[10] 14 Science Drive 4,undefined
[11] Singapore 117543,undefined
[12] Boulder Laboratory for 3D Electron Microscopy of Cells,undefined
[13] Cellular and Developmental Biology,undefined
[14] University of Colorado,undefined
[15] Boulder,undefined
[16] Colorado 80309,undefined
[17] USA,undefined
来源：
Nature | 2008年 / 455卷
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摘要：
The Fc receptor of neonates (FcRn) mediates the apical-to-basolateral transcytosis of immunoglobulin G (IgG) across epithelial cells so that newborns are able to receive maternal antibodies. In this study Her et al. use electron tomography to visualize the transport of IgG during this process with a resolution of 4–6 nm. Individual FcRn ligands were identified inside intracellular organelles using a new gold enlargement technique compatible with high pressure frozen samples. The transcytosis pathways revealed show labelled-Fc moving through networks of vesicles as it migrates from the apical to basolateral surface.
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页码：542 / 546
页数：4
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