53BP1 fosters fidelity of homology-directed DNA repair

被引：0
|
作者：
Fena Ochs
Kumar Somyajit
Matthias Altmeyer
Maj-Britt Rask
Jiri Lukas
Claudia Lukas
机构：
[1] Novo Nordisk Foundation Center for Protein Research,
[2] Faculty of Health and Medical Sciences,undefined
[3] University of Copenhagen,undefined
[4] Present address: Department of Molecular Mechanisms of Disease,undefined
[5] University of Zurich,undefined
[6] Zurich,undefined
[7] Switzerland.,undefined
来源：
Nature Structural & Molecular Biology | 2016年 / 23卷
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摘要：
A new study reveals that 53BP1 influences high-fidelity homology-directed repair by showing that its depletion in the presence of increasing DNA-damage levels triggers a shift from RAD51-dependent gene conversion, an error-free process, to RAD52-mediated single-strand annealing, which is mutagenic.
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页码：714 / 721
页数：7
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