Telomere Length of Individual Chromosomes in Patients with Rheumatoid Arthritis

被引：0
|
作者：
E. A. Blinova
E. V. Zinnatova
M. Sh. Barkovskaya
V. I. Borisov
A. E. Sizikov
V. S. Kozhevnikov
N. B. Rubtsov
V. A. Kozlov
机构：
[1] Research Institute of Fundamental and Clinical Immunology,Federal Research Center Institute of Cytology and Genetics
[2] Siberian Division of the Russian Academy of Sciences,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 160卷
关键词：
telomere length; quantitative fluorescent in situ hybridization; lymphocytes; rheumatoid arthritis; chromosomes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We analyzed telomere length of individual chromosomes in peripheral blood lymphocytes of healthy individuals and patients with rheumatoid arthritis. Quantitative fluorescent in situ hybridization and subsequent computer analysis of metaphase chromosomes showed that distribution of telomere length on individual chromosomes is different under normal and pathological conditions. Patients with rheumatoid arthritis had significantly shorter chromosome 4p telomeres, which can be essential for pathogenesis of this multifactorial disease. Additionally, disease activity inversely correlated with telomere length on chromosome 10p carrying genes involved in T cell differentiation and proliferation.
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页码：779 / 782
页数：3
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