The as-yet unfulfilled promise of p38 MAPK inhibitors

被引：0
|
作者：
Susan E. Sweeney
机构：
[1] Allergy and Immunology,Division of Rheumatology
[2] University of California,undefined
[3] San Diego School of Medicine,undefined
来源：
Nature Reviews Rheumatology | 2009年 / 5卷
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摘要：
Clinical tests of the novel small-molecule inhibitor of p38α MAPK, VX-702, have resulted in an all-too-familiar outcome: modest clinical efficacy and transient inhibition of inflammatory markers. Why have p38α inhibitors failed, and what can we learn about the regulation of signal transduction pathways in inflammatory arthritis?
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页码：475 / 477
页数：2
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