AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

被引：0

作者：

Xiaojiang Gao

Arman Bashirova

Astrid K N Iversen

John Phair

James J Goedert

Susan Buchbinder

Keith Hoots

David Vlahov

Marcus Altfeld

Stephen J O'Brien

Mary Carrington

机构：

[1] Laboratory of Genomic Diversity,Division of Cancer Epidemiology and Genetics

[2] NCI-Frederick,undefined

[3] Basic Research Program,undefined

[4] SAIC Frederick,undefined

[5] P.O. Box B,undefined

[6] Johns Hopkins University School of Medicine,undefined

[7] MRC Human Immunology Unit,undefined

[8] Weatherall Institute of Molecular Medicine,undefined

[9] University of Oxford,undefined

[10] John Radcliffe Hospital,undefined

[11] Howard Brown Health Center and The Fineberg School of Medicine,undefined

[12] Northwestern University,undefined

[13] Viral Epidemiology Branch,undefined

[14] National Cancer Institute,undefined

[15] San Francisco Department of Public Health,undefined

[16] Gulf States Hemophilia Center,undefined

[17] University of Texas Health Science Center,undefined

[18] Center for Urban Epidemiologic Studies,undefined

[19] New York Academy of Medicine,undefined

[20] Partners AIDS Research Center,undefined

[21] Massachusetts General Hospital,undefined

[22] Laboratory of Genomic Diversity,undefined

[23] National Cancer Institute,undefined

[24] P.O. Box B,undefined

[25] Building 560,undefined

来源：

Nature Medicine | 2005年 / 11卷

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摘要：

An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.

引用

页码：1290 / 1292

页数：2

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[1] AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
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Bashirova, A
Iversen, AN
Phair, J
Goedert, JJ
Buchbinder, S
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Altfeld, M
O'Brien, SJ
Carrington, M
[J]. TISSUE ANTIGENS, 2005, 66 (05): : 424 - 424
[2] AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis
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