The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

被引：0
|
作者：
Ravikumar A. Sitapara
Alex G. Gauthier
Sergio I. Valdés-Ferrer
Mosi Lin
Vivek Patel
Mao Wang
Ashley T. Martino
Jeanette C. Perron
Charles R. Ashby
Kevin J. Tracey
Valentin A. Pavlov
Lin L. Mantell
机构：
[1] St. John’s University College of Pharmacy and Health Sciences,Department of Pharmaceutical Sciences, St, College of Pharmacy and Health Sciences
[2] Northwell Health System,Feinstein Institutes for Medical Research
来源：
Molecular Medicine | 2020年 / 26卷
关键词：
Hyperoxia; Lung injury; a7nAChR; Vagus nerve; Cholinergic anti-inflammatory pathway; Inflammatory reflex; Sterile inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 41 条
  • [1] The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation
    Sitapara, Ravikumar A.
    Gauthier, Alex G.
    Valdes-Ferrer, Sergio I.
    Lin, Mosi
    Patel, Vivek
    Wang, Mao
    Martino, Ashley T.
    Perron, Jeanette C.
    Ashby, Charles R., Jr.
    Tracey, Kevin J.
    Pavlov, Valentin A.
    Mantell, Lin L.
    [J]. MOLECULAR MEDICINE, 2020, 26 (01)
  • [2] The selective α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced inflammation and lung injury
    M Kox
    JC Pompe
    M Vaneker
    LM Heunks
    JG Van der Hoeven
    CW Hoedemaekers
    P Pickkers
    [J]. Critical Care, 13 (Suppl 1):
  • [3] ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST (GTS-21) ATTENUATES INTESTINAL INJURY IN SEPSIS
    Xie, Han
    Meng, Qinghe
    Pruekprasert, Napat
    Liu, Yu
    Cooney, Robert
    [J]. SHOCK, 2020, 53 : 67 - 67
  • [4] Inhibition Of Extracellular Hmgb1 Attenuates Hyperoxia-Induced Inflammatory Acute Lung Injury
    Sitapara, R. A.
    Entezari, M.
    Javdan, M.
    Antoine, D. J.
    Morrow, D.
    Patel, V.
    Wang, M.
    Gorasiya, S.
    Zur, M.
    Sharma, L.
    Wu, W.
    Li, J.
    Yang, H.
    Ashby, C.
    Miller, E. J.
    Thomas, D. D.
    Wang, H.
    Mantell, L. L.
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2015, 191
  • [5] Inhibition of extracellular HMGB1 attenuates hyperoxia-induced inflammatory acute lung injury
    Entezari, Maria
    Javdan, Mohammad
    Antoine, Daniel J.
    Morrow, Dympna M. P.
    Sitapara, Ravikumar A.
    Patel, Vivek
    Wang, Mao
    Sharma, Lokesh
    Gorasiya, Samir
    Zur, Michelle
    Wu, Wenjun
    Li, JianHua
    Yang, Huan
    Ashby, Charles R.
    Thomas, Douglas
    Wang, Haichao
    Mantell, Lin L.
    [J]. REDOX BIOLOGY, 2014, 2 : 314 - 322
  • [6] α7 Nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury
    Kox, M.
    Pompe, J. C.
    Peters, E.
    Vaneker, M.
    van der Laak, J. W.
    van der Hoeven, J. G.
    Scheffer, G. J.
    Hoedemaekers, C. W.
    Pickkers, P.
    [J]. BRITISH JOURNAL OF ANAESTHESIA, 2011, 107 (04) : 559 - 566
  • [7] Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory
    Yang, X.
    Zhao, C.
    Chen, X.
    Jiang, L.
    Su, Xiao
    [J]. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, 2017, 110 (07) : 437 - 445
  • [8] α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function
    Ye, Ziping
    Zhu, Yunjuan
    Tang, Nana
    Zhao, Xiaojing
    Jiang, Jingyue
    Ma, Jingjing
    Zhang, Hongjie
    [J]. MOLECULAR MEDICINE, 2022, 28 (01)
  • [9] α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates DSS-induced intestinal colitis by improving intestinal mucosal barrier function
    Ziping Ye
    Yunjuan Zhu
    Nana Tang
    Xiaojing Zhao
    Jingyue Jiang
    Jingjing Ma
    Hongjie Zhang
    [J]. Molecular Medicine, 2022, 28
  • [10] The α7 nicotinic acetylcholine receptor agonist GTS-21 improves bacterial clearance in mice by restoring hyperoxia-compromised macrophage function
    Sitapara, Ravikumar A.
    Gauthier, Alex G.
    Patel, Vivek S.
    Lin, Mosi
    Zur, Michelle
    Ashby, Charles R., Jr.
    Mantell, Lin L.
    [J]. MOLECULAR MEDICINE, 2020, 26 (01)
12345