Human brain activity time-locked to rapid eye movements during REM sleep

被引:0
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作者
Satoru Miyauchi
Masaya Misaki
Shigeyuki Kan
Takahide Fukunaga
Takahiko Koike
机构
[1] National Institute of Information and Communications Technology (NICT),Kobe Advanced ICT Research Center
[2] Japan Science and Technology Agency (JST),CREST
[3] Japan Society for the Promotion of Science (JSPS),undefined
来源
关键词
REM sleep; Rapid eye movements; Saccade; Functional magnetic resonance imaging; Dreaming;
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学科分类号
摘要
To identify the neural substrate of rapid eye movements (REMs) during REM sleep in humans, we conducted simultaneous functional magnetic resonance imaging (fMRI) and polysomnographic recording during REM sleep. Event-related fMRI analysis time-locked to the occurrence of REMs revealed that the pontine tegmentum, ventroposterior thalamus, primary visual cortex, putamen and limbic areas (the anterior cingulate, parahippocampal gyrus and amygdala) were activated in association with REMs. A control experiment during which subjects made self-paced saccades in total darkness showed no activation in the visual cortex. The REM-related activation of the primary visual cortex without visual input from the retina provides neural evidence for the existence of human ponto-geniculo-occipital waves (PGO waves) and a link between REMs and dreaming. Furthermore, the time-course analysis of blood oxygenation level-dependent responses indicated that the activation of the pontine tegmentum, ventroposterior thalamus and primary visual cortex started before the occurrence of REMs. On the other hand, the activation of the putamen and limbic areas accompanied REMs. The activation of the parahippocampal gyrus and amygdala simultaneously with REMs suggests that REMs and/or their generating mechanism are not merely an epiphenomenon of PGO waves, but may be linked to the triggering activation of these areas.
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页码:657 / 667
页数:10
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