The impact of fine particulate matter (PM) on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2

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作者
Se-Ra Park
Joong Won Lee
Seong-Kwan Kim
Wook-Joon Yu
Seung-Jin Lee
Doojin Kim
Kun-Woo Kim
Ji-Won Jung
In-Sun Hong
机构
[1] GAIHST,Department of Health Sciences and Technology
[2] Gachon University,Department of Molecular Medicine, School of Medicine
[3] Gachon University,Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences
[4] Korea National Institute of Health,Developmental and Reproductive Toxicology Research Group
[5] Korea Centers for Disease Control and Prevention,Department of Surgery
[6] Korea Institute of Toxicology,Department of Thoracic and Cardiovascular Surgery
[7] Gachon University Gil Medical Center,undefined
[8] Gachon University School of Medicine,undefined
[9] Gachon University Gil Medical Center,undefined
来源
Experimental & Molecular Medicine | 2021年 / 53卷
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摘要
Fine particulate matter (PM) has a small diameter but a large surface area; thus, it may have broad toxic effects that subsequently damage many tissues of the human body. Interestingly, many studies have suggested that the recent decline in female fertility could be associated with increased PM exposure. However, the precise mechanisms underlying the negative effects of PM exposure on female fertility are still a matter of debate. A previous study demonstrated that resident stem cell deficiency limits the cyclic regenerative capacity of the endometrium and subsequently increases the pregnancy failure rate. Therefore, we hypothesized that PM exposure induces endometrial tissue damage and subsequently reduces the pregnancy rate by inhibiting various beneficial functions of local endometrial stem cells. Consistent with our hypothesis, we showed for the first time that PM exposure significantly inhibits various beneficial functions of endometrial stem cells, such as their self-renewal, transdifferentiation, and migratory capacities, in vitro and in vivo through the PM target gene SERPINB2, which has recently been shown to be involved in multiple stem cell functions. In addition, the PM-induced inhibitory effects on the beneficial functions of endometrial stem cells were significantly diminished by SERPINB2 depletion. Our findings may facilitate the development of promising therapeutic strategies for improving reproductive outcomes in infertile women.
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页码:1850 / 1865
页数:15
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