Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

被引:0
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作者
Matin Chehelgerdi
Fereshteh Behdarvand Dehkordi
Mohammad Chehelgerdi
Hamidreza Kabiri
Hosein Salehian-Dehkordi
Mohammad Abdolvand
Sharareh Salmanizadeh
Mohsen Rashidi
Anoosha Niazmand
Saba Ahmadi
Sara Feizbakhshan
Saber Kabiri
Nasimeh Vatandoost
Tayebeh Ranjbarnejad
机构
[1] Novin Genome (NG) Lab,Young Researchers and Elite Club, Shahrekord Branch
[2] Research and Development Center for Biotechnology,College of Animal Science and Technology
[3] Islamic Azad University,Department of Genetics and Molecular Biology, School of Medicine
[4] China Agricultural University,Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology
[5] Isfahan University of Medical Science,Department Pharmacology, Faculty of Medicine
[6] University of Isfahan,The Health of Plant and Livestock Products Research Center
[7] Mazandaran University of Medical Sciences,Department of Molecular and Medical Genetics
[8] Mazandaran University of Medical Sciences,Pediatric Inherited Diseases Research Center
[9] Tbilisi State Medical University,undefined
[10] Research Institute for Primordial Prevention of Non-Communicable Disease,undefined
[11] Isfahan University of Medical Sciences,undefined
来源
Molecular Cancer | / 22卷
关键词
Induced pluripotent stem cells; Tumorigenesis; Therapy; Regenerative medicine; Personalized medicine; Immunotherapies;
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摘要
The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. The formation of cancer is a multifaceted process influenced by genetic, epigenetic, and environmental factors. iPSCs offer a distinctive platform for investigating the origin of cancer, paving the way for novel approaches to cancer treatment, drug testing, and tailored medical interventions. This review article will provide an overview of the science behind iPSCs, the current limitations and challenges in iPSC-based cancer therapy, the ethical and social implications, and the comparative analysis with other stem cell types for cancer treatment. The article will also discuss the applications of iPSCs in tumorigenesis, the future of iPSCs in tumorigenesis research, and highlight successful case studies utilizing iPSCs in tumorigenesis research. The conclusion will summarize the advancements made in iPSC-based tumorigenesis research and the importance of continued investment in iPSC research to unlock the full potential of these cells.
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