Tet1 controls meiosis by regulating meiotic gene expression

被引:0
|
作者
Shinpei Yamaguchi
Kwonho Hong
Rui Liu
Li Shen
Azusa Inoue
Dinh Diep
Kun Zhang
Yi Zhang
机构
[1] Howard Hughes Medical Institute,Department of Genetics
[2] Harvard Medical School,Departments of Bioengineering
[3] WAB-149G,undefined
[4] 200 Longwood Avenue,undefined
[5] Boston,undefined
[6] Massachusetts 02115,undefined
[7] USA ,undefined
[8] Program in Cellular and Molecular Medicine,undefined
[9] Boston Children’s Hospital,undefined
[10] Harvard Medical School,undefined
[11] WAB-149G,undefined
[12] 200 Longwood Avenue,undefined
[13] Boston,undefined
[14] Massachusetts 02115,undefined
[15] USA ,undefined
[16] Harvard Medical School,undefined
[17] WAB-149G,undefined
[18] 200 Longwood Avenue,undefined
[19] Boston,undefined
[20] Massachusetts 02115,undefined
[21] USA,undefined
[22] University of California at San Diego,undefined
[23] Harvard Stem Cell Institute,undefined
[24] Harvard Medical School,undefined
[25] WAB-149G,undefined
[26] 200 Longwood Avenue,undefined
[27] Boston,undefined
[28] Massachusetts 02115,undefined
[29] USA ,undefined
来源
Nature | 2012年 / 492卷
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学科分类号
摘要
A loss-of-function approach in mice is used to show that the methylcytosine dioxygenase Tet1 has a role in regulating meiosis and meiotic gene activation in female germ cells; Tet1 deficiency does not greatly affect genome-wide demethylation but has a more specific effect on the expression of a subset of meiotic genes.
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页码:443 / 447
页数:4
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