Construction of two new photoluminescent 3D heterometallic complexes and their nursing application values on ICU infection

Two new heterometallic structures of [Zn2Ba(TCA)2(H2O)2]·2n(H2O) (1) and [Cd2Ba(TCA)2(DMA)2(H2O)3]·2n(DMA) (2) were successfully prepared via the solvothermal reactions of 4,4ʹ,4″-ticarboxytriphenylamine (H3TCA) with Zn(NO3)2·6H2O salts and Ba(NO3)2 or Cd(NO3)2·4H2O salts and Ba(NO3)2. The structural characterization results show that complex 1 features a 3D framework structure based on the 1D rod-like heterometal-carboxylate chains while the 3D framework of 2 is constructed from the trinuclear [Cd2Ba(COO)4] cluster. Due to the triphenylamine chromophore of TCA3−, compounds 1–2 show intensive luminescence at room temperature. Their application values on the ICU infection treatment were explored, and we also discussed the corresponding mechanism simultaneously. The utilization of enzyme linked immunosorbent assay detection was done firstly and then content of inflammatory cytokines released into the plasma was determined. Then, the measurement of Toll-like receptor 4 activation was made by real time reverse transcription-polymerase chain reaction. The CCK-8 assay was conducted in this study to evaluate the toxicity of the new compound during treatment.