Endothelin-1 induced bronchial hyperresponsiveness in the rabbit: an ETA receptor-mediated phenomenon

被引：0
|
作者：
B. D'Agostino
L. Gallelli
M. Falciani
P. Di Pierro
F. Rossi
A. Filippelli
F. Rossi
机构：
[1] Institute of Pharmacology and Toxicology,
[2] Faculty of Medicine and Surgery,undefined
[3] 2nd University of Naples,undefined
[4] Via Costantinopoli 16,undefined
[5] 80131 Naples,undefined
[6] Italy,undefined
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 1999年 / 360卷
关键词：
Endothelin-l Bronchial hyperresponsiveness ET-receptors;
D O I：
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学科分类号：
摘要：
Endothelin-1 (ET-1) is a potent and efficacious spasmogen of airway smooth muscle. Recent observations suggest that an increased intrapulmonary production of ET-1 may occur in asthma. Our previous study showed that endothelin-1 induced bronchial hyperresponsiveness to inhaled histamine in the rabbit. The aim of this study was to investigate whether the ETA and ETB receptors mediate the bronchial hyperresponsiveness induced by endothelin-1 in the rabbit.
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页码：665 / 669
页数：4
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