Sustained Intravesical Drug Delivery Using Thermosensitive Hydrogel

被引：0
|
作者：
Pradeep Tyagi
Zhenhua Li
Michael Chancellor
William C. De Groat
Naoki Yoshimura
Leaf Huang
机构：
[1] University of Pittsburgh,Center for Pharmacogenetics, School of Pharmacy
[2] University of Pittsburgh,Department of Urology
[3] University of Pittsburgh,Department of Pharmacology, School of Medicine
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
fluorescien isothiocyanate; hydrogel; misoprostol, urine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. Direct instillation of drug solutions into the bladder through a urethral catheter (i.e., intravesical therapy) evades systemic adverse effects of drugs used for bladder diseases. However, conventional vehicles for these drugs fail to extend duration of drug exposure in the bladder beyond the first voiding of urine postinstillation. The current study seeks to overcome the aforementioned inherent limitation of intravesical drug administration by using thermosensitive hydrogel as a matrix for sustained intravesical drug delivery.
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页码：832 / 837
页数：5
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