Risk factors and hormone-receptor status: epidemiology, risk-prediction models and treatment implications for breast cancer

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作者
Wendy Y Chen
Graham A Colditz
机构
[1] Dana Farber Cancer Institute,WY Chen is an Attending Physician at the Department of Medical Oncology, and Associate Physician at the Department of Medicine
[2] Channing Laboratory,undefined
[3] Brigham and Women's Hospital,undefined
[4] and Instructor of Medicine at Harvard Medical School,undefined
[5] Boston,undefined
[6] MA.,undefined
[7] GA Colditz is the Neiss–Gain Professor in Medicine and Associate Director of Prevention and Control at the Alvin J Siteman Cancer Center,undefined
[8] Washington University School of Medicine,undefined
[9] St Louis,undefined
[10] WA,undefined
[11] USA.,undefined
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摘要
Breast cancer is a heterogeneous group of diseases and hormone receptor status defines important clinical and etiologic differences between breast cancer subtypes. This article reviews the epidemiologic data on differences in risk factor associations by hormone receptor status, and highlights the limitations of commonly used prediction models. The authors describe how receptor status information can be applied to risk analysis for screening and preventive therapies.
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页码:415 / 423
页数:8
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