Systemic Therapy in Soft Tissue Sarcomas: Past, Present and Future

被引：9
|
作者：
Purohit S. [1 ]
Bhise R. [1 ]
Appachu S. [1 ]
Lakshmaiah K.C. [1 ]
Govindbabu K. [1 ]
机构：
[1] Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore, -560029, Dr M.H Marigowda road
来源：
Indian Journal of Surgical Oncology | 2011年 / 2卷 / 4期
关键词：
Adjuvant chemotherapy; Soft tissue sarcoma; Trabectedin;
D O I：
10.1007/s13193-012-0140-8
中图分类号：
学科分类号：
摘要：
Soft tissue sarcomas (STS) comprise 1% of all cancers diagnosed worldwide with more than 40 different histological subtypes each with distinct underlying biology, natural history and response to treatment. Due to the differential chemosensitivity it is imperative to have a correct histological diagnosis for optimal treatment of these patients. Even though surgery remains the primary modality of treatment there is increasing specialization of chemotherapy with respect to histological subtype. In general there is no place for "one size fits all strategy". To correctly define the role of chemotherapy, an extensive search was carried out online and offline for all relevant articles concerning chemotherapy in soft tissue sarcoma. This review aims to discuss the evolution of chemotherapy, its present role in neoadjuvant, adjuvant, metastatic settings and exciting trends with the advent of targeted therapies. © 2012 Indian Association of Surgical Oncology.
引用
收藏
页码：327 / 331
页数：4
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