Dissociation between individual differences in self-reported pain intensity and underlying fMRI brain activation

被引:16
|
作者
Hoeppli, M. E. [1 ,2 ]
Nahman-Averbuch, H. [1 ,2 ,3 ,4 ]
Hinkle, W. A. [1 ]
Leon, E. [1 ,2 ]
Peugh, J. [2 ,5 ]
Lopez-Sola, M. [6 ]
King, C. D. [1 ,2 ,5 ]
Goldschneider, K. R. [1 ,7 ]
Coghill, R. C. [1 ,2 ,5 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Pediat Pain Res Ctr PPRC, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Div Behav Med & Clin Psychol, Cincinnati, OH 45229 USA
[3] Washington Univ, Sch Med, Div Clin & Translat Res, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Anesthesiol, Washington Univ Pain Ctr, St Louis, MO 63110 USA
[5] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA
[6] Univ Barcelona, Sch Med & Hlth Sci, Dept Med, Serra Hunter Programme, Barcelona, Spain
[7] Cincinnati Childrens Hosp Med Ctr, Pain Management Ctr, Dept Anesthesiol, Cincinnati, OH 45229 USA
关键词
INDEPENDENT COMPONENT ANALYSIS; INFORMATION-SYSTEM PROMIS(R); VISUAL ANALOG; NOXIOUS HEAT; ITEM BANK; SCALE; RESPONSES; ANXIETY; STIMULI; CORTEX;
D O I
10.1038/s41467-022-31039-3
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Previous work had suggested that fMRI measures can be used as a marker of pain experience. Here the authors find no evidence for a link between perceived pain intensity and fMRI activation. Pain is an individual experience. Previous studies have highlighted changes in brain activation and morphology associated with within- and interindividual pain perception. In this study we sought to characterize brain mechanisms associated with between-individual differences in pain in a sample of healthy adolescent and adult participants (N = 101). Here we show that pain ratings varied widely across individuals and that individuals reported changes in pain evoked by small differences in stimulus intensity in a manner congruent with their pain sensitivity, further supporting the utility of subjective reporting as a measure of the true individual experience. Furthermore, brain activation related to interindividual differences in pain was not detected, despite clear sensitivity of the Blood Oxygenation Level-Dependent (BOLD) signal to small differences in noxious stimulus intensities within individuals. These findings suggest fMRI may not be a useful objective measure to infer reported pain intensity.
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页数:14
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