A role for Lin28 in primordial germ-cell development and germ-cell malignancy

被引：0
|
作者：
Jason A. West
Srinivas R. Viswanathan
Akiko Yabuuchi
Kerianne Cunniff
Ayumu Takeuchi
In-Hyun Park
Julia E. Sero
Hao Zhu
Antonio Perez-Atayde
A. Lindsay Frazier
M. Azim Surani
George Q. Daley
机构：
[1] Children’s Hospital Boston and the Dana-Farber Cancer Institute,Division of Pediatric Hematology/Oncology
[2] Harvard Medical School,Department of Biological Chemistry and Molecular Pharmacology
[3] Harvard Stem Cell Institute,Department of Pathology
[4] Boston,undefined
[5] Massachusetts 02115,undefined
[6] USA,undefined
[7] Children’s Hospital Boston and Harvard Medical School,undefined
[8] Boston,undefined
[9] Massachusetts 02115,undefined
[10] USA,undefined
[11] Channing Laboratory,undefined
[12] Brigham and Women’s Hospital,undefined
[13] Harvard Medical School,undefined
[14] Boston,undefined
[15] Massachusetts 02115,undefined
[16] USA ,undefined
[17] Wellcome Trust Cancer Research UK Gurdon Institute of Cancer and Developmental Biology,undefined
[18] University of Cambridge,undefined
[19] Tennis Court Road,undefined
[20] Cambridge CB2 1QN,undefined
[21] UK ,undefined
[22] Manton Center for Orphan Disease Research,undefined
[23] Boston,undefined
[24] Massachusetts 02115,undefined
[25] USA ,undefined
[26] Howard Hughes Medical Institute,undefined
[27] Boston,undefined
[28] Massachusetts 02115,undefined
[29] USA ,undefined
来源：
Nature | 2009年 / 460卷
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摘要：
An RNA interference screen of 30 gene candidates has identified Lin28, a negative regulator of let-7 microRNA processing, as a potentially key regulator of primordial germ cell development, the process in the developing embryo that selects the cells destined to produce sperm and eggs. In addition, Lin28 levels are elevated in primary human germ cell tumours, suggesting that it may also be implicated in germ cell malignancy.
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页码：909 / 913
页数：4
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