Osteogenesis imperfecta: New treatment options

被引：7
|
作者：
Chevrel G. [1 ]
Cimaz R. [1 ]
机构：
[1] Department of Pediatrics, Edouard Herrriot Hospital, 69437 Lyon Cedex 03, 5, place d'Arsonval
来源：
Current Rheumatology Reports | 2006年 / 8卷 / 6期
关键词：
Bone Mineral Density; Alendronate; Osteogenesis Imperfecta; Pamidronate; Strontium Ranelate;
D O I：
10.1007/s11926-006-0044-0
中图分类号：
学科分类号：
摘要：
Classic treatments of osteogenesis imperfecta for children and adults include rehabilitation therapy and orthopedic surgery. New treatments include bisphosphonates. Among them, the effects of intravenous pamidronate have been primarily evaluated in children in several open cohorts. Treatments of adult patients are not established. Several other treatments may have an effect on the fracture rate. However, further studies are needed to demonstrate an effect on fracture rate in children and adult patients. A new approach has been developed to replace mutated genes using mesenchymal stem cells and a construct, which inactivates COL1A1. Copyright © 2006 by Current Science Inc.
引用
收藏
页码：474 / 479
页数：5
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