Fatty Acids and their Proteins in Adipose Tissue Inflammation

被引:0
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作者
Rahul Mallick
Sanjay Basak
Ranjit K. Das
Antara Banerjee
Sujay Paul
Surajit Pathak
Asim K. Duttaroy
机构
[1] University of Eastern Finland,A.I. Virtanen Institute for Molecular Sciences
[2] Indian Council of Medical Research,Molecular Biology Division, ICMR
[3] Department of Health and Biomedical Sciences,National Institute of Nutrition
[4] University of Texas Rio Grande Valley,Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Department of Medical Biotechnology
[5] Faculty of Allied Health Sciences,Tecnologico de Monterrey, School of Engineering and Sciences
[6] Campus Queretaro,Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine
[7] University of Oslo,undefined
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关键词
Metabolic syndrome; Dietary fats; n-3 PUFA; LCPUFA; Obesity; Inflammation;
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摘要
Chronic low-grade adipose tissue inflammation is associated with metabolic disorders. Inflammation results from the intertwined cross-talks of pro-inflammatory and anti-inflammatory pathways in the immune response of adipose tissue. In addition, adipose FABP4 levels and lipid droplet proteins are involved in systemic and tissue inflammation. Dysregulated adipocytes help infiltrate immune cells derived from bone marrow responsible for producing cytokines and chemokines. When adipose tissue expands in excess, adipocyte exhibits increased secretion of adipokines and is implicated in metabolic disturbances due to the release of free fatty acids. This review presents an emerging concept in adipose tissue fat metabolism, fatty acid handling and binding proteins, and lipid droplet proteins and their involvement in inflammatory disorders.
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页码:35 / 51
页数:16
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