Success in tubulysin D synthesis

被引：0
|
作者：
Florenz Sasse
Dirk Menche
机构：
[1] the Department of Chemical Biology and Medicinal Chemistry at the Helmholtz-Zentrum für Infektionsforschung GmbH,
来源：
Nature Chemical Biology | 2007年 / 3卷
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摘要：
The tubulysins inhibit tubulin polymerization, which makes them potent antiproliferative agents and promising lead candidates for the development of new anticancer drugs. The first total synthesis of the most potent member of the tubulysin family, tubulysin D, has been accomplished in a highly convergent manner using an innovative synthetic strategy.
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页码：87 / 89
页数：2
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