Mechanisms Underlying the Effects of Ultralow Doses of Antibodies to Granulocytic Colony-Stimulating Factor on Recovery of Damaged Pancreatic Tissue in Experimental Diabetes Mellitus

被引：0
|
作者：
N. N. Ermakova
V. V. Zhdanov
A. M. Dygai
G. N. Zyuz’kov
L. A. Stavrova
L. A. Gur’yantseva
T. Yu. Khrichkova
E. V. Udut
T. V. Vetoshkina
T. I. Fomina
L. A. Ermolaeva
E. D. Goldberg
机构：
[1] Siberian Division of Russian Academy of Medical Sciences,Institute of Pharmacology, Tomsk Research Center
来源：
Bulletin of Experimental Biology and Medicine | 2009年 / 148卷
关键词：
ultralow doses of antibodies; granulocytic colony-stimulating factor; diabetes mellitus; alloxan;
D O I：
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学科分类号：
摘要：
Using the model of alloxan-induced diabetes mellitus on rats we demonstrated the effect of ultralow doses of antibodies to granulocytic colony-stimulating factor on recovery of the pancreas and normalization of blood glucose concentration. The preparation produced antiinfl ammatory and antisclerotic effects associated with activation of stem cells and their determined homing into the pancreas.
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页码：549 / 552
页数：3
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