Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates: a factor for differing results of TPMT measurements

被引：0

作者：

T. Kröplin

C. Fischer

H. Iven

机构：

[1] Department of Pharmacology,

[2] Lübeck Medical University,undefined

[3] Ratzeburger Allee 160,undefined

[4] D-23538 Lübeck,undefined

[5] Germany Tel.: +49-451-500-2682; Fax: +49-451-500-2686,undefined

[6] Dr. Fischer Bosch Institute of Clinical Pharmacology,undefined

[7] Stuttgart,undefined

[8] Germany,undefined

来源：

European Journal of Clinical Pharmacology | 1999年 / 55卷

关键词：

Key words Thiopurine methyltransferase polymorphism;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Objectives: Thiopurine S-methyltransferase (TPMT) activity, when measured in red blood cells (RBC) with a recently published TPMT activity assay using 6‐thioguanine (6-TG) as substrate, could not be reproduced in another laboratory. We investigated factors which could influence the results of the TPMT activity measurement.

引用

页码：285 / 291

页数：6

共 13 条

[1] Inhibition of thiopurine S-methyltransferase activity by impurities in commercially available substrates:: a factor for differing results of TPMT measurements
Kröplin, T
Fischer, C
Iven, H
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 55 (04) : 285 - 291
[2] Thiopurine S-methyltransferase activity (TPMT) is modulated by disease
Iven, H
Kotalczyk, A
Gutsche, S
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2005, 371 : R136 - R136
[3] Thiopurine S-methyltransferase (TPMT) Activity Is Better Determined by Biochemical Assay Versus Genotyping in the Jewish Population
Yair Kasirer
Rephael Mevorach
Paul Renbaum
Nurit Algur
Devora Soiferman
Rachel Beeri
Yelana Rachman
Reeval Segel
Dan Turner
Digestive Diseases and Sciences, 2014, 59 : 1207 - 1212
[4] Thiopurine S-methyltransferase (TPMT) Activity Is Better Determined by Biochemical Assay Versus Genotyping in the Jewish Population
Kasirer, Yair
Mevorach, Rephael
Renbaum, Paul
Algur, Nurit
Soiferman, Devora
Beeri, Rachel
Rachman, Yelana
Segel, Reeval
Turner, Dan
DIGESTIVE DISEASES AND SCIENCES, 2014, 59 (06) : 1207 - 1212
[5] Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT*3A, TPMT*2): Mechanisms for the genetic polymorphism of TPMT activity
Tai, HL
Krynetski, EY
Schuetz, EG
Yanishevski, Y
Evans, WE
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) : 6444 - 6449
[6] Different mechanisms behind low enzyme activity in vivo of two different variants of Thiopurine S-methyltransferase, TPMT
Wennerstrand, P.
Martensson, L. -G.
Dametto, P.
Hennig, J.
Skoglund, K.
Peterson, C.
FEBS JOURNAL, 2010, 277 : 257 - 258
[7] Study of the concordance between the enzymatic activity of Thiopurine S-methyltransferase and polymorphisms in the TPMT gene in patients with Inflammatory Bowel Disease
Cespedes Martinez, E.
Robles-Alonso, V.
Castellote, L.
Bravo-Nieto, D.
Serra, X.
Herrera-De Guise, C.
Mayorga, L.
Perez, Z.
Oller, E.
Garriga-Edo, S.
Casellas, F.
Borruel, N.
JOURNAL OF CROHNS & COLITIS, 2024, 18 : I1480 - I1481
[8] Structural Characteristics Determine the Cause of the Low Enzyme Activity of Two Thiopurine S-Methyltransferase Allelic Variants: A Biophysical Characterization of TPMT*2 and TPMT*5
Wennerstrand, Patricia
Dametto, Paolo
Hennig, Janosch
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BIOCHEMISTRY, 2012, 51 (30) : 5912 - 5920
[9] Thiopurine S-methyltransferase activity in Japanese subjects:: metabolic activity of 6-mercaptopurine 6-methylation in different TPMT genotypes
Nishida, A
Kubota, T
Yamada, Y
Higashi, K
Kitamura, K
Nakahara, K
Iga, T
CLINICA CHIMICA ACTA, 2002, 323 (1-2) : 147 - 150
[10] Association between TPMT*3C and decreased thiopurine S-methyltransferase activity in patients with neuromyelitis optica spectrum disorders in China
Gong, Xiaoqing
Mei, Shenghui
Li, Xindi
Li, Xingang
Zhou, Heng
Liu, Yonghong
Zhou, Anna
Yang, Li
Zhao, Zhigang
Zhang, Xinghu
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2018, 128 (06) : 549 - 553

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