Successful experience of tofacitinib treatment in patients with Fibrodysplasia Ossificans Progressiva

被引：0

作者：

Irina P. Nikishina

Svetlana V. Arsenyeva

Valeria G. Matkava

Alia N. Arefieva

Mariya I. Kaleda

Alexandr V. Smirnov

Leonid M. Blank

Mikhail M. Kostik

机构：

[1] V.A. Nasonova Research Institute of Rheumatology,

[2] Hospital Pediatry Department of Saint-Petersburg State Pediatric Medical University,undefined

来源：

Pediatric Rheumatology | / 21卷

关键词：

Fibrodysplasia ossificans progressiva; FOP; Heterotopic ossification; Tofacitinib; Autoinflammation; Spondyloarthritis-like disease; gene; Bone morphogenetic protein; BMP;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Fibrodysplasia ossificans progressive (FOP) is an ultra-rare genetic disorder that is caused by a mutation in the ACVR1 gene and provokes severe heterotopic ossification. Since flares of the disease are associated with inflammation, it is assumed that JAK inhibitors can control active FOP due to blocking multiple signaling pathways.

引用

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[1] Successful experience of tofacitinib treatment in patients with Fibrodysplasia Ossificans Progressiva
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