Synthesis of 4-(trifluoromethyl)pyrido[4,3-d]pyrimidine derivatives

被引：0
|
作者：
L. S. Vasil’ev
S. V. Baranin
A. V. Ignatenko
Yu. V. Nelyubina
V. A. Dorokhov
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
Key words; 4-alkoxy-1,4-dihydropyrido[4,3-; ]pyrimidines; 4-hydroxy-1,4-dihydropyri-do[4,3-; ]pyrimidine; pyrido[4,3-; ]pyrimidines; 4-trifluoromethyl-substituted heterocycles;
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学科分类号：
摘要：
Earlier unknown 4-alkoxy-and 4-hydroxy-5-methyl-4-trifluoromethyl-1,4-dihydropyri-do[4,3-d]pyrimidines were obtained by the reaction of 5-acetyl-4-dimethylaminovinyl-6-(trifluoromethyl)pyrimidine with alcoholic (aqueous) solutions of NH3. The former eliminate alcohol (water) on sublimation in vacuo to be converted to 5-methyl-4-(trifluoromethyl)-pyrido[4,3-d]pyrimidine. The latter upon the action of alcohols (water) under mild conditions were reverted to the corresponding 4-alkoxy-and 4-hydroxydihydropyrido[4,3-d]pyrimidines.
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页码：1403 / 1407
页数：4
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