Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury

被引：0
|
作者：
Pascale Boulenguez
Sylvie Liabeuf
Rémi Bos
Hélène Bras
Céline Jean-Xavier
Cécile Brocard
Aurélie Stil
Pascal Darbon
Daniel Cattaert
Eric Delpire
Martin Marsala
Laurent Vinay
机构：
[1] Laboratoire Plasticité et Physio-Pathologie de la Motricité (UMR6196),Department of Anesthesiology
[2] Centre National de la Recherche Scientifique (CNRS) & Aix-Marseille Université,Department of Anesthesiology
[3] Centre de Neurosciences Intégratives et Cognitives,undefined
[4] CNRS & Université de Bordeaux,undefined
[5] Vanderbilt University Medical Center,undefined
[6] Anesthesiology Research Laboratory,undefined
[7] University of California–San Diego,undefined
[8] Institute of Neurobiology,undefined
[9] Slovak Academy of Sciences,undefined
[10] Present addresses: Biozentrum,undefined
[11] Department of Cell Biology,undefined
[12] University of Basel,undefined
[13] Basel,undefined
[14] Switzerland and Friedrich Miescher Institute for Biomedical Research,undefined
[15] Basel,undefined
[16] Switzerland (C.J.-X.) and Institut des Neurosciences Cellulaires et Intégratives,undefined
[17] UPR3212 CNRS-Université de Strasbourg,undefined
[18] Département Nociception et Douleur,undefined
[19] Strasbourg,undefined
[20] France (P.D.).,undefined
来源：
Nature Medicine | 2010年 / 16卷
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学科分类号：
摘要：
Muscle spasticity is a major problem for individuals with SCI. Now, Laurent Vinay and his colleagues report that downregulation of the potassium-chloride cotransporter in spinal cord motor neurons after SCI has a key role in the development of spasticity (pages 270–271).
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页码：302 / 307
页数：5
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