Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1

被引：0
|
作者：
Yunlong Li
Zhijiang Miao
Pengfei Li
Ruyi Zhang
Denis E. Kainov
Zhongren Ma
Robert A. de Man
Maikel P. Peppelenbosch
Qiuwei Pan
机构：
[1] Erasmus MC-University Medical Center,Department of Gastroenterology and Hepatology
[2] Norwegian University of Science and Technology,Department of Clinical and Molecular Medicine
[3] University of Tartu,Institute of Technology
[4] Northwest Minzu University,Biomedical Research Center
来源：
Archives of Virology | 2021年 / 166卷
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摘要：
We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin.
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页码：2005 / 2010
页数：5
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