The delivery of angiogenic factors to the heart by microsphere therapy

被引：0
|
作者：
Margarete Arras
Hanke Mollnau
Rudolf Strasser
Robert Wenz
Wulf Ito
Jutta Schaper
Wolfgang Schaper
机构：
[1] Department of Experimental Cardiology,Max
[2] Merck KGaA,Planck
来源：
Nature Biotechnology | 1998年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Microspheres offer the possibility of local noninvasive delivery of drugs over an extended period of time. We adsorbed fibroblast growth factor (FGF) to microspheres of precapillary size that were injected via a coronary catheter. We showed that FGF was released from these microspheres and taken up by endothelial cells, which proliferated following translocation of FGF to the nucleus. This method for application of growth factors allows the precise delivery of angiogenic substances to any selected part of the heart or other organs without causing inflammation or ischemia.
引用
收藏
页码：159 / 162
页数：3
相关论文
共 50 条
  • [1] The delivery of angiogenic factors to the heart by microsphere therapy
    Arras, M
    Mollnau, H
    Strasser, R
    Wenz, R
    Ito, WD
    Schaper, J
    Schaper, W
    [J]. NATURE BIOTECHNOLOGY, 1998, 16 (02) : 159 - 162
  • [2] Angiogenic therapy of the human heart
    Folkman, J
    [J]. CIRCULATION, 1998, 97 (07) : 628 - 629
  • [3] Microsphere delivery of Risperidone as an alternative to combination therapy
    D'Souza, Susan
    Faraj, Jabar
    DeLuca, Patrick
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2013, 85 (03) : 631 - 639
  • [4] Therapeutic angiogenesis: controlled delivery of angiogenic factors
    Chu, Hunghao
    Wang, Yadong
    [J]. THERAPEUTIC DELIVERY, 2012, 3 (06) : 693 - 714
  • [5] Sequential delivery of angiogenic growth factors improves revascularization and heart function after myocardial infarction
    Awada, Hassan K.
    Johnson, Noah R.
    Wang, Yadong
    [J]. JOURNAL OF CONTROLLED RELEASE, 2015, 207 : 7 - 17
  • [6] Biopolymeric delivery matrices for angiogenic growth factors
    Zisch, AH
    Lutolf, MP
    Hubbell, JA
    [J]. CARDIOVASCULAR PATHOLOGY, 2003, 12 (06) : 295 - 310
  • [7] Biodegradable progesterone microsphere delivery system for osteoporosis therapy
    Yang, Q
    Owusu-Ababio, G
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2000, 26 (01) : 61 - 70
  • [8] Prognostic Impact of Circulating Angiogenic Factors in 90Y Microsphere Treatment
    Mavi, Mehmet Emin
    Volkan-Salanci, Bilge
    Lay, Incilay
    Eldem, Fatma Gonca
    Peynircioglu, Bora
    Yalcin, Suayib
    Ugur, Omer
    Bozkurt, Murat Fani
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2023, 64
  • [9] A THERAPY INACTIVATING THE TUMOR ANGIOGENIC FACTORS
    Morales-Rodrigo, Cristian
    [J]. MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2013, 10 (01) : 185 - 198
  • [10] Expression of angiogenic factors by photodynamic therapy
    Rudolf, M
    Michels, S
    Schlötzer-Schrehardt, U
    Schmidt-Erfurth, U
    [J]. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 2004, 221 (12) : 1026 - 1032
12345