Negative regulation of the deacetylase SIRT1 by DBC1

被引：0

作者：

Wenhui Zhao

Jan-Philipp Kruse

Yi Tang

Sung Yun Jung

Jun Qin

Wei Gu

机构：

[1] Institute for Cancer Genetics,and Department of Pathology College of Physicians and Surgeons

[2] Columbia University,Departments of Biochemistry and Cell Biology

[3] 1130 St Nicholas Avenue,undefined

[4] New York,undefined

[5] New York 10032,undefined

[6] USA,undefined

[7] Baylor College of Medicine,undefined

[8] One Baylor Plaza,undefined

[9] Houston,undefined

[10] Texas 77030,undefined

[11] USA,undefined

来源：

Nature | 2008年 / 451卷

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学科分类号：

摘要：

The deacetylase SIRT1, the mammalian version of the Sir2 protein that plays a critical role in determining lifespan in yeast, has been implicated in various cellular functions and possibly in tumorigenesis and ageing. The factors regulating SIRT1 are not well known but two groups now report that the tumour suppressor DBC1 is a negative regulator of SIRT1. By inhibiting SIRT1, DBC1 promotes increased acetylation of the tumour suppressor p53 and p53-mediated apoptosis in human cells.

引用

页码：587 / 590

页数：3

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